Why the study?
To describe the rationale, study design, and recruitment of the first population-based randomized controlled CT screening trial for cardiovascular disease, powered to detect reduced CHD morbidity and mortality.
Does population-based screening using traditional risk factors or Coronary Artery Calcium scoring reduce Coronary Heart Disease morbidity and mortality in asymptomatic high-risk individuals?
Population
43,447 asymptomatic high-risk men (45-74 years) and women (55-74 years)
Comparison
Traditional risk factor screening vs CAC scoring screening vs usual care
Design
Population-based randomized controlled trial
Key result
Population-based screening using traditional risk factors or coronary artery calcium scoring was initiated in 43,447 randomized asymptomatic high-risk individuals to assess CHD outcomes.
Authors
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Initiates first large RCT of population CHD screening with CAC or risk factors; leaves clinical impact open pending outcome data.
RCT (n=43,447)
1:1:1
Does population-based screening using traditional risk factors or Coronary Artery Calcium scoring reduce Coronary Heart Disease morbidity and mortality in asymptomatic high-risk individuals?
The ROBINSCA trial is the first population-based randomized-controlled CT screening trial designed to determine if screening for cardiovascular disease reduces CHD morbidity and mortality.
Aalst et al. (2019) conducted an RCT in Cardiovascular Disease (n=43,447). Screening for traditional risk factors or Coronary Artery Calcium scoring vs. Usual care was evaluated on Coronary Heart Disease (CHD) morbidity and mortality. Population-based screening using traditional risk factors or coronary artery calcium scoring was initiated in 43,447 randomized asymptomatic high-risk individuals to assess CHD outcomes.