Key result
Dexmedetomidine significantly improved memory function at 30 days post-surgery compared to midazolam in patients undergoing coronary artery bypass graft surgery (WMS score 103.53 vs 87.60, p=0.005).
Why the study?
Postoperative cognitive decline is common after general anesthesia, prompting an evaluation of the effects of dexmedetomidine versus midazolam during CABG surgery on cognitive and memory function.
Does dexmedetomidine improve postoperative cognitive and memory function compared to midazolam in patients undergoing elective on-pump CABG?
Population
42 elective on-pump CABG candidates aged 40 to 65 years
Comparison
Dexmedetomidine 1 µg/kg vs midazolam 0.05–0.1 mg/kg
Design
Randomized clinical trial
Follow-up
30 days after surgery
Authors
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Dexmedetomidine may better preserve cognition than midazolam after CABG; extends small RCT data on sedation choice in cardiac surgery.
RCT (n=42)
Double-blind
Electronically randomized method
Yes
Does dexmedetomidine improve postoperative cognitive and memory function compared to midazolam in patients undergoing elective on-pump CABG?
Absolute Event Rate: 103.53% vs 87.6%
p-value: p=0.005
Dexmedetomidine may have a lower impact on postoperative cognitive and memory function compared to midazolam in patients undergoing CABG.
Rajaei et al. (2019) conducted an RCT in Postoperative cognitive impairment (n=42). Dexmedetomidine vs. Midazolam (0.05–0.1 mg/kg) was evaluated on Wechsler Memory Scale (WMS) score at 30 days after surgery (p=0.005). Dexmedetomidine significantly improved memory function at 30 days post-surgery compared to midazolam in patients undergoing coronary artery bypass graft surgery (WMS score 103.53 vs 87.60, p=0.005).
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