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March 1, 2012The Anatolian Journal of Cardiology

Short stature is an independent risk marker for mortality and incident coronary heart disease only in women: a structural relationship?

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Key result

In Turkish women, a 1-SD increment (6.5 cm) in height significantly predicted a lower risk of all-cause death (HR 0.83), whereas height was not significantly associated with mortality in men.

Why the study?

Is short stature associated with increased risk of incident coronary heart disease and overall mortality in adults?

Population

3394 Turkish adults, mean age 44±11 years

Comparison

Short stature vs Taller stature

Design

Cohort

Follow-up

mean 13.5 years

Authors

AOAltan OnatHiroshima UniversityEÖEnder ÖrnekBilkent UniversityGCGünay CanHiroshima University

Discussion

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Implication

Should not change risk stratification; leaves open sex-specific height-mortality links in observational cohorts.

Study Design

Type

Cohort (n=3,394)

Multicenter

Yes

Structured PICO

Is short stature associated with increased risk of incident coronary heart disease and overall mortality in adults?

P
Population
3,394 Turkish adults (mean age 44 years, 50% female) followed for a mean of 13.5 years to evaluate the association of body height with mortality and incident coronary heart disease.
E
Exposure
Short stature (evaluated as continuous variable, tertiles, and threshold below 160 cm)
C
Comparator
Taller stature
O
Outcome
Incident coronary heart disease (CHD) and overall mortalityhard clinical

Main Result

Hazard Ratio: 0.83 (95% CI 0.59–0.98)

Short stature (below 160 cm) is an independent risk marker for all-cause mortality and tends to be a risk marker for incident coronary heart disease specifically in women, but not in men.

Limitations

  • Relatively limited sample size
  • Comparatively brief follow-up period
  • Applicability to different ethnicities may be limited due to the high prevalence of metabolic syndrome and HDL dysfunction in the Turkish population

Cite This Study

Onat et al. (2012) conducted a cohort in Coronary heart disease and overall mortality (n=3,394). 1-SD increment (6.5 cm) in height vs. Shorter stature was evaluated on All-cause death in women (HR 0.83, 95% CI 0.59-0.98). In Turkish women, a 1-SD increment (6.5 cm) in height significantly predicted a lower risk of all-cause death (HR 0.83), whereas height was not significantly associated with mortality in men.

synapsesocial.com/papers/6a9e474c6dfa5258fec3c97ahttps://doi.org/10.5152/akd.2012.091
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Short stature is associated with coronary heart disease: a systematic review of the literature and a meta-analysis2010 · 341 citations
  2. 2Cardiovascular Survey Methods.1968 · 3,067 citations
  3. 3Short stature and risk for mortality and cardiovascular disease events. The Framingham Heart Study.1994 · 107 citations
  4. 4Prevalence of lower-extremity amputation among patients with diabetes mellitus: Is height a factor?2006 · 58 citations
  5. 5Association between Height and Coronary Heart Disease Mortality: A Prospective Study of 35,000 Twin Pairs2006 · 91 citations