Nanomaterial‐based advanced immunoassays

Immunoassay has been the main stream in clinic diagnostics and still attracts extensive research interest in recent years to develop reliable, fast, sensitive, and specific detection methods and platforms to expand its applications in various areas including proteomics, drug discovery, homeland security, food safety, environmental monitoring, and health care. With the dramatic progress in material science, nanotechnology, and bioconjugation techniques, a great diversity of nanomaterials with desirable superior properties have been designed, synthesized, and tailored to facilitate high‐performance detections for advanced immunoassays. This paper comprehensively reviews recent advances in nanomaterial‐based immunoassay technologies and particularly highlights newly developed strategies associated with interdisciplinary areas for performance enhancement and related mechanisms. The future perspectives of immunosensing technologies are also discussed. WIREs Nanomed Nanobiotechnol 2011 3 119–133 DOI: 10.1002/wnan.124 This article is categorized under: Diagnostic Tools > Biosensing Therapeutic Approaches and Drug Discovery > Emerging Technologies Diagnostic Tools > In Vitro Nanoparticle-Based Sensing