Towards the establishment of treatments for neurodegenerative diseases using human iPSCs

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Since their discovery and development, human induced pluripotent stem cells (iPSCs) have brought about notable advances in biomedical science and have become an essential infrastructure for medical research and applications. This review discusses the current status of iPSC-based cell therapies, drug discovery, and therapeutic developments for neurodegenerative diseases with unmet medical needs. It also highlights research approaches employing cohorts of iPSCs derived from sporadic neurodegenerative diseases to advance prevention and diagnostic support. It further considers future directions for the use of iPSCs in the treatment of neurodegenerative disorders.