Key result
In pregnant women with mechanical heart valves, management predominantly with LMWH throughout pregnancy resulted in one valve thrombosis (5.3%), compared to two thromboses (8.0%) with a sequential LMWH/VKA strategy.
Why the study?
Pregnant women with mechanical heart valves face significant risk of obstetric and cardiac complications, prompting a comparison of anticoagulation management across two obstetric cardiac centres.
Does anticoagulation strategy (LMWH throughout vs LMWH then VKA) affect the risk of mechanical heart valve thrombosis in pregnant women with mechanical heart valves?
Comparison
Anticoagulation management at CR vs EMC
Design
Retrospective case-note review from two centres
Authors
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Management inconsistencies in pregnant patients with mechanical valves warrant standardized protocols; leaves open optimal regimen pending prospective data.
Observational (n=44)
Yes
Does anticoagulation strategy (LMWH throughout vs LMWH then VKA) affect the risk of mechanical heart valve thrombosis in pregnant women with mechanical heart valves?
Absolute Event Rate: 5.3% vs 8%
This retrospective review highlights significant inconsistencies in peri-partum anticoagulation strategies, monitoring, and delivery modes for pregnant women with mechanical heart valves across two specialized centers.
Santos et al. (2020) conducted an observational in Pregnant women with mechanical heart valves (n=44). Anticoagulation management strategies (LMWH throughout pregnancy vs. sequential LMWH/VKA) vs. Between-center comparison was evaluated on Mechanical heart valve thrombosis. In pregnant women with mechanical heart valves, management predominantly with LMWH throughout pregnancy resulted in one valve thrombosis (5.3%), compared to two thromboses (8.0%) with a sequential LMWH/VKA strategy.
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