Key result
The VE/VCO2 peak during cardiopulmonary exercise testing predicted angiographically confirmed coronary artery disease with an area under the curve of 0.73 (95% CI 0.54-0.9; p=0.05).
Why the study?
Does cardiopulmonary exercise testing predict the development of myocardial ischaemia in men with suspected coronary artery disease?
Cross-Sectional (n=31)
Does cardiopulmonary exercise testing predict the development of myocardial ischaemia in men with suspected coronary artery disease?
Effect estimate: AUC 0.73 (95% CI 0.54 to 0.9)
p-value: p=0.05
In men with suspected coronary artery disease, the VE/VCO2 peak during cardiopulmonary exercise testing demonstrated moderate diagnostic accuracy (AUC 0.73) for identifying myocardial ischemia.
May support CPET parameters for ischemia prediction in suspected CAD; leaves open prospective validation before clinical use.
OBJECTIVE: The aim of this study is to assess different parameters of cardiopulmonary exercise testing that can predict the development of myocardial ischaemia in patients with suspected coronary artery disease (CAD) and to identify the parameters which have more correlation with myocardial ischaemia. STUDY DESIGN: Cross-sectional study. METHODS: In this study, a total of 31 men (mean age 57.23±11.09 years) with suggestive symptoms of CAD underwent an exercise stress test with breath-by-breath gas exchange analysis, followed by coronary angiography as the gold standard for diagnosing CAD. RESULTS: The ventilation versus CO2 output (VE/VCO2) peak was significantly different between patients with negative and positive angiography results. Receiver operator characteristic analysis showed an area under the curve of 0.73 for VE/VCO2 peak with diagnostic threshold equal to 35 (95% CI 0.54 to 0.9; p=0.05). Exercise stress testing had sensitivity and specificity of 75% and 40%, respectively. CONCLUSIONS: A change in ventilatory efficiency assessed using the VE/VCO2 peak has the predictive ability to identify exercise-induced myocardial ischaemia. The present study has provided additional evidence of the potential clinical value of cardiopulmonary exercise testing in the diagnosis of CAD.
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Mazaheri et al. (2016) conducted a cross-sectional in suspected coronary artery disease (n=31). Cardiopulmonary exercise testing (VE/VCO2 peak) was evaluated on Myocardial ischaemia on coronary angiography (AUC 0.73, 95% CI 0.54 to 0.9, p=0.05). The VE/VCO2 peak during cardiopulmonary exercise testing predicted angiographically confirmed coronary artery disease with an area under the curve of 0.73 (95% CI 0.54-0.9; p=0.05).
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