Key result
Co-induction with midazolam and thiopentone resulted in an induction time of 35.5 seconds, which was significantly shorter than midazolam alone (75.2 seconds) and provided better cardiovascular stability than thiopentone alone.
Why the study?
Does co-induction with midazolam and thiopentone improve induction characteristics and safety compared to either agent alone in ASA grade I and II patients?
RCT (n=150)
Double-blind
Randomized
No
Does co-induction with midazolam and thiopentone improve induction characteristics and safety compared to either agent alone in ASA grade I and II patients?
Co-induction with midazolam and thiopentone offers a smoother and safer anesthesia induction profile compared to using either agent individually.
Supports midazolam-thiopentone co-induction for faster, stable induction in ASA I-II patients; confirms advantages over single-agent regimens.
This study was undertaken to compare the induction characteristics of conventional thiopentone sodium, midazolam, and a combination of midazolam and thiopentone sodium as co-induction agent. Total one hundred and fifty patients of ASA grade I and II were divided into three groups in a double blind randomized study. Group-I received midazolam 0.25 mgkg-1 intravenously, group-II received thiopentone sodium 5 mgkg-1 intravenously and Group-III received midazolam 0.1 mg/kg-1 IV followed by thiopentone sodium 2.5 mg/kg-1 IV. Induction time was significantly prolonged with midazolam (group-II) compared to thiopentone sodium. The fall in systolic blood pressure (SBP) and diastolic blood pressure (DBP) was clinically insignificant in midazolam group. Induction with midazolam was not smooth and was associated with unwanted movement of limbs. Incidence of apnoea, pain, thrombophlebites were significantly less with midazolam. Co-induction with midazolam and thiopentone significantly reduced the induction time, unwanted movements of limbs, apnoea during induction and cardiovascular stability was also more in co-induction group than thiopenfone sodium group. Incidence and duration of drowsiness was also significantly lesser in coinduction group. These advantages signifies that combination of midazolan and thiopentone is better choice for induction of anaesthesia than the other conventional induction agent like individual midazolam or thiopentone.DOI: http://dx.doi.org/10.3329/jbsa.v17i1.4047 Journal of BSA, Vol. 17, No. 1 & 2, 2004 p.23-27
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Rahman et al. (2009) conducted an RCT in General anesthesia induction (n=150). Midazolam and thiopentone co-induction vs. Thiopentone 5 mg/kg or Midazolam 0.25 mg/kg was evaluated on Induction time (seconds) (p=<0.05). Co-induction with midazolam and thiopentone resulted in an induction time of 35.5 seconds, which was significantly shorter than midazolam alone (75.2 seconds) and provided better cardiovascular stability than thiopentone alone.
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