Key result
Perimortal tissue acidosis in AMI hearts was associated with a significantly lower endocardial/epicardial ratio of CKMBmass compared to non-AMI hearts (0.53 vs 0.92; P<0.005).
Population
20 hearts from patients who died from noncardiac causes without history of cardiac complaints, 6 hearts from…
Design
Preclinical
Authors
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Supports acidosis-mediated CKMB inactivation in AMI; leaves open translation to human autopsy diagnostics.
Observational (n=190)
Absolute Event Rate: 0.53% vs 0.92%
p-value: p=<0.005
Perimortal tissue acidosis (pH 5.0-5.5) causes rapid inactivation of CKMB, explaining its absence in myocardial tissue at autopsy and resolving a long-standing biomarker controversy.
Boumans et al. (2001) conducted an observational in Acute myocardial infarction (n=190). Perimortal tissue acidosis (AMI) vs. Non-AMI hearts was evaluated on Transmural ratio (endocardial/epicardial) of CKMBmass (p=<0.005). Perimortal tissue acidosis in AMI hearts was associated with a significantly lower endocardial/epicardial ratio of CKMBmass compared to non-AMI hearts (0.53 vs 0.92; P<0.005).
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