Key result
Higher serum A-FABP levels were independently associated with aortic stiffness in patients who have undergone CABG (OR 1.068; 95% CI 1.017-1.121; p=0.008).
Why the study?
Aortic stiffness independently predicts mortality after CABG, and higher A-FABP predicts aortic stiffness in hypertension or diabetes, but its relationship in CABG patients requires investigation.
Are age and serum A-FABP levels associated with aortic stiffness in patients who have undergone CABG?
Observational (n=84)
Are age and serum A-FABP levels associated with aortic stiffness in patients who have undergone CABG?
Higher serum A-FABP levels and older age are independently associated with increased aortic stiffness in patients who have undergone CABG.
Answers are grounded in this paper and cite their sources.
A-FABP may mark aortic stiffness post-CABG; hypothesis-generating and should not yet change practice.
Old age has been proven to be related to progressed arterial or aortic stiffness. Aortic stiffness is an independent predictor of all-cause and cardiovascular disease mortalities in patients who have undergone coronary artery bypass grafting (CABG) surgery. Higher serum concentrations of adipocyte fatty-acid-binding protein (A-FABP) could be considered a predictor of aortic stiffness in patients with hypertension or diabetes mellitus. This study aims to investigate the relationships between A-FABP and aortic stiffness in patients who have received CABG. A total of 84 CABG patients were enrolled in our study from September 2018 to May 2019. Serum A-FABP levels were determined using a commercial enzyme immunoassay. Carotid−femoral pulse wave velocity (cfPWV) > 10 m/s was defined as aortic stiffness. Of the 84 CABG patients, 28 (33.3%) with aortic stiffness had a higher average age; exhibited higher rates of diabetes; and had higher serum creatinine, C-reactive protein, and A-FABP levels compared to controls. Multivariable logistic regression revealed that serum A-FABP levels (odds ratio (OR) = 1.068, 95% confidence interval (CI) 1.017−1.121, p = 0.008) and age (OR = 1.204, 95% CI 1.067−1.359, p = 0.003) were independent predictors of aortic stiffness. Multivariable stepwise linear regression revealed significant positive correlations of age and A-FABP levels with cfPWV values. Serum A-FABP level is positively correlated with cfPWV values, and a high serum A-FABP level is associated with aortic stiffness in patients who have undergone CABG.
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Huang et al. (2022) conducted an observational in Aortic stiffness (n=84). Serum A-FABP levels vs. Patients without aortic stiffness was evaluated on Aortic stiffness (cfPWV > 10 m/s) (OR 1.068, 95% CI 1.017-1.121, p=0.008). Higher serum A-FABP levels were independently associated with aortic stiffness in patients who have undergone CABG (OR 1.068; 95% CI 1.017-1.121; p=0.008).
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