Key result
Electron microscopy remains a valuable and rapid technique for the detection and identification of unknown or unsuspected viruses in clinical specimens, emerging diseases, and potential bioterrorism agents.
Electron microscopy remains a valuable tool for clinical viral diagnosis, surveillance of emerging diseases, and research into viral ultrastructure and pathogenesis.
Retains role in rapid viral detection amid molecular methods; extends literature review evidence to emerging diseases and bioterrorism.
Electron microscopy, considered by some to be an old technique, is still on the forefront of both clinical viral diagnoses and viral ultrastructure and pathogenesis studies. In the diagnostic setting, it is particularly valuable in the surveillance of emerging diseases and potential bioterrorism viruses. In the research arena, modalities such as immunoelectron microscopy, cryo-electron microscopy, and electron tomography have demonstrated how viral structural components fit together, attach to cells, assimilate during replication, and associate with the cellular machinery during replication and egression. These studies provide information for treatment and vaccine strategies.
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Goldsmith et al. (2009) conducted a review in Viral infections. Electron Microscopy was evaluated. Electron microscopy remains a valuable and rapid technique for the detection and identification of unknown or unsuspected viruses in clinical specimens, emerging diseases, and potential bioterrorism agents.
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