Key result
Plasma homocysteine levels were significantly higher in male patients with restenosis after PTCA compared to those without restenosis (15.0 ± 3.9 vs. 13.0 ± 2.9 micromol/L; P=0.011).
Why the study?
Do elevated plasma homocysteine levels predict restenosis in male patients after successful elective PTCA?
Observational (n=112)
Do elevated plasma homocysteine levels predict restenosis in male patients after successful elective PTCA?
Absolute Event Rate: 15% vs 13%
p-value: p=0.011
Elevated plasma homocysteine levels are associated with an increased risk of angiographic restenosis after successful elective PTCA, suggesting it as a potential therapeutic target.
Elevated homocysteine may identify men at higher restenosis risk after PTCA; leaves open whether lowering it reduces events.
We examined the relationship between plasma homocysteine levels and restenosis after PTCA (Percutaneous transluminal coronary angioplasty) to investigate whether plasma homocysteine levels can be a predictor of restenosis after PTCA. One hundred and twelve male patients who have undergone a successful elective PTCA were consecutively enrolled and plasma homocysteine levels were measured at the time of follow-up angiography. Plasma homocysteine levels in patients with restenosis were significantly higher than those in patients without restenosis (15.0 +/- 3.9 vs. 13 +/- 2.9 micromol/L; P = 0.011). The difference was augmented when diabetic patients were selectively studied. The comparison between restenosis group and non-restenosis group indicated the threshold effect of hyperhomocysteinemia. These results suggest that plasma homocysteine is a potential risk factor of restenosis after PTCA, and therapeutic strategy targeted against hyperhomocysteinemia may be beneficial for preventing restenosis.
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A 2000 study conducted an observational in Restenosis after PTCA (n=112). Plasma homocysteine levels vs. Patients without restenosis was evaluated on Plasma homocysteine levels in patients with vs without restenosis (p=0.011). Plasma homocysteine levels were significantly higher in male patients with restenosis after PTCA compared to those without restenosis (15.0 ± 3.9 vs. 13.0 ± 2.9 micromol/L; P=0.011).
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