Key result
Immunofluorescence studies of cardiac tissues from a patient with severe rheumatic myocarditis revealed large monocytoid Aschoff cells containing traces of cardiac myosin.
Case Report (n=1)
Immunofluorescence of florid rheumatic Aschoff lesions reveals monocytoid cells containing traces of cardiac myosin, suggesting macrophage-mediated phagocytosis of damaged myocardial fibers.
Answers are grounded in this paper and cite their sources.
Supports phagocytic role of Aschoff cells in rheumatic myocarditis; leaves open mechanistic relevance pending larger studies.
We studied cardiac tissues of a patient who died of severe rheumatic myocarditis. Multiple Aschoff lesions were present throughout both ventricles and auricles. Immunofluorescence studies showed large monocytoid cells staining with OKM1 and anti-Leu M-3 as well as anti-Ia. Scattered T cells in areas of focal myocarditis stained with OKT3. Parallel staining for cardiac myosin-heavy chain antigens showed patchy dissolution of cardiac muscle fibers and traces of cardiac myosin within large monocytoid Aschoff cells.
No takes yet. Share an insight, caveat, or question.
Husby et al. (1986) conducted a case report in Severe rheumatic myocarditis (n=1). Immunofluorescence studies was evaluated on Immunofluorescence staining characteristics of Aschoff lesions. Immunofluorescence studies of cardiac tissues from a patient with severe rheumatic myocarditis revealed large monocytoid Aschoff cells containing traces of cardiac myosin.
Synapse has enriched 10 related papers. Consider them for comparative context: