Key result
Among 543 necropsy patients with severe chronic valvular heart disease, Aschoff bodies were found in 2% (11 patients), all of whom had diffuse fibrous thickening of the mitral valve leaflets.
Population
543 necropsy patients over age 14 years with severe chronic valvular heart disease
Design
Cross-sectional
Authors
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Exclusive mitral fibrosis link supports rheumatic primacy; leaves open prospective validation before refining diagnostics.
Observational (n=543)
In patients with chronic valvular heart disease, the presence of Aschoff bodies is exclusively associated with diffuse anatomic lesions of the mitral valve, indicating that rheumatic heart disease is primarily a disease of the mitral valve.
Roberts et al. (1978) conducted an observational in Severe chronic valvular heart disease (n=543). Severe chronic valvular heart disease was evaluated on Presence of Aschoff bodies. Among 543 necropsy patients with severe chronic valvular heart disease, Aschoff bodies were found in 2% (11 patients), all of whom had diffuse fibrous thickening of the mitral valve leaflets.
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