Population
316 biopsies of atrial appendages obtained at mitral valvotomy from patients with mitral stenosis, and a…
Design
Cross-sectional
Authors
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May indicate prolonged subclinical rheumatic activity in mitral stenosis; leaves open whether histology should inform intervention timing.
Histologic activity of the rheumatic process may continue for 20 years or more in patients with mitral stenosis, even in the absence of clinical signs and symptoms.
Ruebner et al. (1961) studied this question.
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