Key result
Multiple sclerosis was associated with subclinical left ventricular dysfunction, indicated by increased LV end-systolic dimension and decreased LV ejection fraction compared to controls (P<0.05).
Why the study?
Do patients with multiple sclerosis have subclinical left and right ventricular dysfunction compared to healthy controls?
Case-Control (n=73)
Do patients with multiple sclerosis have subclinical left and right ventricular dysfunction compared to healthy controls?
p-value: p=<0.05
Patients with multiple sclerosis exhibit subclinical left ventricular dysfunction but preserved right ventricular function compared to healthy controls.
OBJECTIVES: To investigate the left (LV) and right ventricular (RV) function in multiple sclerosis (MS) using standard echocardiography and Doppler tissue imaging (DTI). MATERIALS AND METHODS: A total of 41 patients with definite MS and 32 healthy controls were included in the study. RESULTS: LV end-systolic dimension was increased and LV ejection fraction was decreased in MS patients compared with controls (P < 0.05). LV end-diastolic dimension was increased in MS patients, however, did not reach significance. Among DTI parameters, mitral annular peak early diastolic velocity to peak late diastolic velocity ratio (Em/Am) was decreased in MS patients, but not reach statistical significance. No significant differences in tricuspid annular Em/Am ratio was found between MS patients and controls. A statistically significant increase of DTI derived LV myocardial performance index was found in MS patients as compared with controls. RV myocardial performance index showed a tendency to be increased in MS patients, however, did not reach significance. CONCLUSIONS: These findings suggest subclinical LV dysfunction and preserved RV function in patients with MS.
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Akgül et al. (2006) conducted a case-control in Multiple sclerosis (n=73). Multiple sclerosis vs. Healthy controls was evaluated on Left ventricular end-systolic dimension and ejection fraction (p=<0.05). Multiple sclerosis was associated with subclinical left ventricular dysfunction, indicated by increased LV end-systolic dimension and decreased LV ejection fraction compared to controls (P<0.05).
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