Key result
Multiple sclerosis was associated with increased QTc intervals compared with controls (P < 0.01), which correlated with a reduction of spinal cord area (P < 0.01).
Why the study?
Are QTc abnormalities in multiple sclerosis associated with spinal cord atrophy on MRI?
Observational (n=52)
Are QTc abnormalities in multiple sclerosis associated with spinal cord atrophy on MRI?
p-value: p=<0.01
QTc abnormalities in multiple sclerosis are associated with axonal loss, reflected by spinal cord atrophy, rather than demyelination.
Ventricular repolarization dysfunction has recently been reported in multiple sclerosis (MS). We evaluated ventricular repolarization dysfunction in 52 MS patients and looked for a relationship between corrected QT (QTc) abnormalities (i.e., abnormalities of QT intervals corrected for rate) and spinal cord magnetic resonance imaging (MRI) findings. QTc intervals were increased in MS patients compared with controls (P < 0.01) and were correlated with a reduction of spinal cord area (P < 0.01). QTc abnormalities in MS were thus associated with axonal loss, reflected by spinal cord atrophy, rather than demyelination.
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Sèze et al. (2000) conducted an observational in Multiple sclerosis (n=52). Multiple sclerosis vs. Controls was evaluated on QTc intervals (p=<0.01). Multiple sclerosis was associated with increased QTc intervals compared with controls (P < 0.01), which correlated with a reduction of spinal cord area (P < 0.01).
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