Key result
Multiple sclerosis was associated with significantly prolonged ventricular repolarization (QTc interval) compared to control subjects (P = 0.0001).
Why the study?
Is ventricular repolarization (QTc interval) prolonged in patients with multiple sclerosis compared to control subjects?
Observational (n=48)
Is ventricular repolarization (QTc interval) prolonged in patients with multiple sclerosis compared to control subjects?
Multiple sclerosis is associated with significantly prolonged ventricular repolarization (QTc interval), a finding also confirmed in a rat model.
Ventricular repolarization was investigated for the first time in 48 multiple sclerosis (MS) patients using measurement of QTc interval on standard electrocardiographic recordings. The repolarization process was prolonged significantly in MS compared to control subjects (P = 0.0001). This result was confirmed with an animal model of MS, i.e., the experimental allergic encephalomyelitis in rat. The contribution of prolonged QT to syncopal attack or sudden cardiac death in MS patients need further investigation.
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Drouin et al. (1998) conducted an observational in Multiple sclerosis (n=48). Multiple sclerosis vs. Control subjects was evaluated on QTc interval prolongation (p=0.0001). Multiple sclerosis was associated with significantly prolonged ventricular repolarization (QTc interval) compared to control subjects (P = 0.0001).
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