Key result
Lacunar infarction was associated with a higher prevalence of microalbuminuria compared to controls (32.8% vs 9.8%, P<0.001), with age, alcohol, glucose, and blood pressure as key risk factors.
Why the study?
The study was conducted to investigate the prevalence and risk factors for microalbuminuria in patients with lacunar infarction.
What is the prevalence and what are the risk factors for microalbuminuria in patients with lacunar infarction?
Case-Control (n=936)
What is the prevalence and what are the risk factors for microalbuminuria in patients with lacunar infarction?
Absolute Event Rate: 32.8% vs 9.8%
p-value: p=<0.001
Lacunar infarction is associated with a significantly higher prevalence of microalbuminuria, with age, alcohol abuse, fasting blood glucose, and systolic blood pressure identified as independent risk factors.
Microalbuminuria may be more common in lacunar infarction; this case-control study leaves open prognostic value and screening utility.
Objectives: To investigate the prevalence and risk factors for microalbuminuria in patients with lacunar infarction.Methods: 702 lacunar infarction patients and 234 controls were recruited in this study, the concentration of urinary albumin and clinical characteristics were collected for each participant. We analyzed the prevalence of microalbuminuria in lacunar infarction patients, as well as the risk factors of microalbuminuria in patients with lacunar infarction.Results: The prevalence of microalbuminuria in patients with lacunar infarction was 32.8%, which was significantly higher than that in controls (9.8%, P＜0.001). Multiple linear regression analysis indicated that age, alcohol abuse, fasting blood glucose, systolic blood pressure, and triglyceride were positively associated with albumin/creatinine ratio levels. Multiple logistic regression analysis indicated that age (odds ratio [OR] = 1.067, 95% confidence interval [CI] = 1.029 to 1.105), alcohol abuse (OR = 3.001, 95% CI = 1.668 to 5.398), fasting blood glucose (OR = 2.014, 95% CI = 1.794 to 2.260), and systolic blood pressure (OR = 1.033, 95% CI = 1.010 to 1.056) were the independent risk factors for microalbuminuria in acute lacunar infarction patients, with high sensitivity, specificity, positive predictive value, and negative predictive value. Receiver operating characteristic curve analysis showed that the area under the curve for age, systolic blood pressure, and fasting blood glucose were 0.618 (cutoff value, 63.5 years; sensitivity, 54.8%; and specificity, 62.9%), 0.736 (cutoff level, 149.5 mmHg; sensitivity, 78.3%; and specificity, 61.2%) and 0.893 (cutoff value, 7 mmol/L; sensitivity, 92.2%; and specificity, 86%), respectively.Conclusion: Lacunar infarction was associated with higher microalbuminuria prevalence. Age, alcohol abuse, fasting blood glucose, and systolic blood pressure were individually significant and correlated factors of microalbuminuria in patients with lacunar infarction. More attention should be provided to this group of patients.
No takes yet. Share an insight, caveat, or question.
Li et al. (2019) conducted a case-control in Lacunar infarction (n=936). Lacunar infarction vs. Controls was evaluated on Prevalence of microalbuminuria (p=<0.001). Lacunar infarction was associated with a higher prevalence of microalbuminuria compared to controls (32.8% vs 9.8%, P<0.001), with age, alcohol, glucose, and blood pressure as key risk factors.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: