Key result
Creating a colorectal anastomosis with an insufficient number of sutures in a rat model significantly increased the rate of anastomotic leakage to 68.8% compared to 10% in the 12-suture control group.
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Insufficient sutures raise leak risk in rat models; leaves open translation to human colorectal surgery.
In colorectal surgery, anastomotic leakage (AL) is known to be a frequent and life-threatening complication. The literature reports incidences of 5 to 17% of cases AL is associated with morbidity and mortality: AL patients undergo more radiological diagnostics, need prolonged Intensive Care Unit (ICU) admission, require more re-operations, require the construction of stomas, and, although debated, might even suffer from higher local and distant oncological recurrence rates and decreased long-term survival
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Barneveld et al. (2016) studied Colorectal Anastomotic Leakage (n=44). Insufficient anastomosis (3, 4, or 5 sutures) vs. 12 sutures (control) was evaluated on Percentage of anastomotic leakage (AL) (p=0.005). Creating a colorectal anastomosis with an insufficient number of sutures in a rat model significantly increased the rate of anastomotic leakage to 68.8% compared to 10% in the 12-suture control group.
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