Key result
Breast cancer patients with positive epithelial and low stromal periostin expression had the lowest mortality risk, whereas those with high or low expression in both compartments had the worst outcomes.
Why the study?
Does the pattern of stromal and epithelial periostin expression predict mortality in women with breast cancer?
Population
200 women with breast cancer, tumour samples obtained at the time of mastectomy
Design
Cohort
Follow-up
median 18.7 years (range 0.5-29.5 years)
Authors
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PN epithelial/stromal IHC patterns may refine long-term mortality risk stratification in breast cancer; leaves open validation in larger prospective cohorts.
Cohort (n=200)
No
Does the pattern of stromal and epithelial periostin expression predict mortality in women with breast cancer?
The combined pattern of epithelial and stromal periostin expression may serve as an independent prognostic signature for mortality in breast cancer patients.
Nuzzo et al. (2016) conducted a cohort in Breast cancer (n=200). Stromal and epithelial periostin expression vs. Different expression patterns (e.g., low vs high expression) was evaluated on All-cause and breast cancer-specific mortality. Breast cancer patients with positive epithelial and low stromal periostin expression had the lowest mortality risk, whereas those with high or low expression in both compartments had the worst outcomes.
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