Severe Toxic Reactions Associated With Sulfamethoxypyridazine (Kynex)

Article1 July 1959SEVERE TOXIC REACTIONS ASSOCIATED WITH SULFAMETHOXYPYRIDAZINE (KYNEX)J. SALVAGGIO, M.D., F. GONZALEZ, M.D.J. SALVAGGIO, M.D.Search for more papers by this author, F. GONZALEZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-1-60 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe ever-increasing problem of bacterial resistance to antibiotics has caused a "shift of the pendulum" back to the usage of sulfonamides in recent years. This fact has again brought into the spotlight the clinical toxicity of these chemotherapeutic agents. With the development of newer and more soluble compounds, renal toxicity has virtually ceased to exist, and there has been a marked decline of other types of reactions to these drugs. In his evaluation of the newer sulfonamides, Yow1has listed their injurious effects as follows: fever, 1.5%; dermatitis, 1.5%; gastrointestinal toxicity, 1.3%; blood dyscrasias, 0.18%; hepatitis, 0.1%; renal toxicity, anaphylaxis,...Bibliography1. Yow EM: A re-evaluation of sulfonamide therapy, Ann. Int. Med. 43: 323, 1955. LinkGoogle Scholar2. Lehr D: Clinical toxicity of sulfonamides, Ann. New York Acad. Sc. 69: 417, 1957. CrossrefMedlineGoogle Scholar3. RoepkeMarenMayer RRTHE: Experimental investigations of sulfamethoxypyridazine, Ann. New York Acad. Sc. 69: 457, 1957. CrossrefMedlineGoogle Scholar4. WalkerHamburger WFM: Clinical experiences with sulfamethoxypyridazine, Ann. New York Acad. Sc. 69: 509, 1957. CrossrefMedlineGoogle Scholar5. FriskWassen ARA: Clinical evaluation of sulfamethoxypyridazine, in Antibiotics annual, 1956-1957, 1957, Medical Encyclopedia, Inc., New York, p. 424. Google Scholar6. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Orleans, Louisiana*Received for publication February 9, 1959.From the Department of Medicine, Louisiana State University School of Medicine, and the Medical Service, Charity Hospital of Louisiana, New Orleans, Louisiana.†Product of Lederle Laboratories, Division, American Cyanamid Company.Requests for reprints should be addressed to John E. Salvaggio, M.D., Charity Hospital of Louisiana, 1532 Tulane Avenue, New Orleans, Louisiana. 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WEINBERGER, M.D.Fatal Exfoliative Dermatitis after SulfamethoxypyridazineThe Sulfonamides 1 July 1959Volume 51, Issue 1Page: 60-67KeywordsAdverse reactionsHospital medicineInflammationMedical servicesNauseaNecrosisRespiratory systemSulfonamideToxicityUrticaria ePublished: 1 December 2008 Issue Published: 1 July 1959 PDF downloadLoading ...