Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 13, 2014GeneticsOpen Access

The Distribution of Pairwise Genetic Distances: A Tool for Investigating Disease Transmission

View Full Paper
Ask AI
Bookmark
Share

Key result

An analytically tractable approximation of pairwise genetic distances provided robust estimation of transmission route probabilities and successfully ruled out potential transmission links in an MRSA outbreak.

Population

Genomic data from an outbreak of methicillin-resistant Staphylococcus aureus

Design

Other

Authors

CWColin J. WorbyHCHsiao‐Han ChangWHWilliam P. Hanage

Discussion

Loading...

Member takes

Overview

May improve WGS interpretation in outbreaks; leaves open reliable transmission inference without strong assumptions.

Structured PICO

P
Population
Genomic data from an outbreak of methicillin-resistant Staphylococcus aureus
E
Exposure
Analytically tractable approximation to the distribution of pairwise genetic distances
O
Outcome
Estimation of the posterior probability of transmission routes

The proposed analytical approximation of pairwise genetic distances provides a computationally efficient tool for inferring disease transmission dynamics during outbreaks.

Cite This Study

Worby et al. (2014) studied Methicillin-resistant Staphylococcus aureus (MRSA) outbreak. Analytically tractable approximation of pairwise genetic distances was evaluated on Posterior probability of transmission routes. An analytically tractable approximation of pairwise genetic distances provided robust estimation of transmission route probabilities and successfully ruled out potential transmission links in an MRSA outbreak.

synapsesocial.com/papers/6a9e66b60802d747abf6dffbhttps://doi.org/10.1534/genetics.114.171538
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Uncovering heterogeneous intercommunity disease transmission from neutral allele frequency time series2025
  2. 2Uncovering heterogeneous intercommunity disease transmission from neutral allele frequency time series2025 · 2 citations
  3. 3Phylogenetic inference of inter-population transmission rates for infectious diseases2024 · 1 citations
  4. 4A Systematic Bayesian Integration of Epidemiological and Genetic Data2015 · 68 citations
  5. 5Fast hospital discharge rates blur within-hospital 'transmission footprint' in bacterial genomes, as showcased with Staphylococcus aureus.2026