Key result
In preterm neonates, systolic blood pressure decreased by 30% with isoflurane, 25% with halothane, 21% with fentanyl, and 16% with ketamine, with severe drops least frequent with ketamine (P<0.02).
Why the study?
Does the choice of anesthetic (isoflurane, halothane, fentanyl, or ketamine) affect hemodynamic stability in preterm neonates?
Population
80 preterm neonates
Comparison
0.75% isoflurane, 0.5% halothane, 20… vs Active comparators
Design
Other
Follow-up
until surgical stimulation
Authors
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May support ketamine for hemodynamic stability in preterm neonates; hypothesis-generating, needs randomized confirmation before practice change.
Does the choice of anesthetic (isoflurane, halothane, fentanyl, or ketamine) affect hemodynamic stability in preterm neonates?
p-value: p=<0.01
In preterm neonates, ketamine provides better hemodynamic stability with less frequent clinically important decreases in systolic blood pressure compared to isoflurane, halothane, or fentanyl.
Friesen et al. (1986) studied Preterm neonates requiring anesthesia (n=80). Isoflurane, halothane, fentanyl, and ketamine vs. Active comparators was evaluated on Changes in systolic blood pressure (SAP) and mean blood pressure (MAP) (p=<0.01). In preterm neonates, systolic blood pressure decreased by 30% with isoflurane, 25% with halothane, 21% with fentanyl, and 16% with ketamine, with severe drops least frequent with ketamine (P<0.02).
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