Key result
Anesthesia with ketamine resulted in a 16% decrease in systolic blood pressure, compared to 30% with isoflurane, 25% with halothane, and 21% with fentanyl in preterm neonates (P<0.01).
Why the study?
Does the choice of anesthetic (isoflurane, halothane, fentanyl, or ketamine) affect hemodynamic stability in preterm neonates?
Population
80 preterm neonates
Comparison
0.75% isoflurane, 0.5% halothane, 20… vs Active comparators
Design
Cohort
Follow-up
until surgical stimulation
Authors
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Ketamine may minimize hypotension in preterm neonates; hypothesis-generating and requires randomized confirmation before practice change.
RCT (n=80)
Does the choice of anesthetic (isoflurane, halothane, fentanyl, or ketamine) affect hemodynamic stability in preterm neonates?
p-value: p=<0.01
In preterm neonates, ketamine is associated with a lower incidence of clinically important decreases in systolic blood pressure compared to isoflurane, halothane, or fentanyl.
Friesen et al. (1986) conducted an RCT in Preterm neonates requiring anesthesia (n=80). Ketamine vs. Isoflurane (0.75%), halothane (0.5%), or fentanyl (20 micrograms/kg) was evaluated on Changes in systolic blood pressure (SAP) and mean blood pressure (MAP) (p=<0.01). Anesthesia with ketamine resulted in a 16% decrease in systolic blood pressure, compared to 30% with isoflurane, 25% with halothane, and 21% with fentanyl in preterm neonates (P<0.01).
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