A novel hypothesis for pathophysiology of hepatitis fibrosis in hepatitis C viral infection

We present a novel hypothesis on the pathophysiology of Hepatitis fibrosis in hepatitis C viral (HCV) infection which takes into account the possibility that fibrosis in HCV infection in its pre-cirrhotic phase is a defensive mechanism to encapsulate the invading HCV and prevent further dissemination. This theory contrasts the idea that fibrosis in HCV infection is an ineffective complication. A presentation of the complex bidirectional interactions of the fibrosis in the space of Disse during this process is illustrated. Finally, based on this hypothesis, a novel therapeutic regimen is considered.