Key result
In vivo mast cell stabilization using ketotifen and cromolyn improved cardiac peak systolic pressure, contractility, and relaxation compared with hemorrhagic shock controls (P < 0.05).
Why the study?
Does mast cell stabilization improve cardiac contractile function in a rat model of hemorrhagic shock and resuscitation?
Population
Anesthetized male Sprague-Dawley rats undergoing hemorrhagic shock and resuscitation
Comparison
Mast cell stabilizers administered 15 min before… vs Saline or sham-operated control
Design
Preclinical, Randomized to sham-operated control or HS/R groups; animals in…
Follow-up
60 min of hemorrhagic shock followed by 2 h of…
Authors
Loading...
Mast cell stabilization may preserve contractility in rat hemorrhagic shock; leaves open translation to human resuscitation protocols.
RCT
randomized
Does mast cell stabilization improve cardiac contractile function in a rat model of hemorrhagic shock and resuscitation?
p-value: p=< 0.05
Mast cell stabilization prevents cardiac contractile dysfunction following hemorrhagic shock and resuscitation in a preclinical rat model.
Santone et al. (2008) conducted an RCT in Hemorrhagic shock and resuscitation. Mast cell stabilizers (cromolyn or ketotifen) vs. Saline (hemorrhagic shock controls) or sham-operated control was evaluated on Cardiac peak systolic pressure, contractility, and relaxation (p=< 0.05). In vivo mast cell stabilization using ketotifen and cromolyn improved cardiac peak systolic pressure, contractility, and relaxation compared with hemorrhagic shock controls (P < 0.05).
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: