Key result
Hypertonic saline with dextran improves cardiac function during reperfusion without reducing myocardial ischemic injury.
Why the study?
The effects of hypertonic saline with or without dextran-70 on cardiac function and myocardial damage during reperfusion after acute myocardial ischemia were unclear.
Does hypertonic saline with or without dextran improve cardiac function and reduce myocardial damage during reperfusion after acute myocardial ischemia in a porcine model?
Population
Three-month-old male crossbred pigs subjected to 45 mins left anterior descending artery occlusion
Comparison
Hypertonic saline (7.5%) without or with dextran-70 (6%) vs normal saline (0.9%)
Design
Prospective randomized controlled animal study
Follow-up
240 mins
Authors
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HSD may enhance postischemic hemodynamics in animals; leaves open any role in human reperfusion without supporting HS use.
RCT
randomized
No
Does hypertonic saline with or without dextran improve cardiac function and reduce myocardial damage during reperfusion after acute myocardial ischemia in a porcine model?
In a porcine model of myocardial ischemia-reperfusion, hypertonic saline with dextran improved hemodynamics and contractility without exacerbating myocardial injury, challenging previous suggestions of detrimental effects.
Waagstein et al. (1999) conducted an RCT in acute myocardial ischemia and reperfusion. Hypertonic saline without (HS) or with dextran (HSD) vs. normal saline (0.9%) was evaluated on cardiac function and myocardial damage. Administration of hypertonic saline with dextran, but not hypertonic saline alone, improved hemodynamics and myocardial performance during reperfusion without affecting myocardial ischemic injury.
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