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December 1, 2011Acta Physiologica Hungarica

Circulatory consequences of reduced endogenous nitric oxide production during small-volume resuscitation

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Why the study?

Does diminished endogenous NO production influence the circulatory effects of hypertonic saline-dextran resuscitation in normovolemic anesthetized dogs?

Population

14 normovolemic anesthetized dogs

Comparison

Small volume hypertonic saline-dextran infusion… vs Small volume hypertonic saline-dextran infusion…

Design

Preclinical

Follow-up

2 hours postinfusion

Authors

GMGábor MolnárECEndre CsonkaUniversity of SzegedAVAndrea Vass

Discussion

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Implication

Diminished NO may blunt HSD benefits and favor vasoconstriction; hypothesis-generating for NO modulation in resuscitation.

Structured PICO

Does diminished endogenous NO production influence the circulatory effects of hypertonic saline-dextran resuscitation in normovolemic anesthetized dogs?

P
Population
14 normovolemic anesthetized dogs
I
Intervention
Small volume hypertonic saline-dextran (HSD, 7.5% NaCl-10% dextran; 4 ml/kg iv) infusion with pre-treatment with the non-selective NOS inhibitor N-nitro-L-arginine (NNA, 4 mg/kg) (n=7)
C
Comparator
Small volume hypertonic saline-dextran (HSD) infusion without NOS inhibitor pre-treatment (n=7)
O
Outcome
Circulatory effects including cardiac index (CI), coronary flow (CF), and myocardial contractilitysurrogate

Diminished endogenous nitric oxide synthesis abolishes the beneficial hemodynamic effects of hypertonic saline-dextran resuscitation, leading to vasoconstriction.

Cite This Study

Molnár et al. (2011) studied this question.

synapsesocial.com/papers/6a70394c26a7f98052dcbadehttps://doi.org/10.1556/aphysiol.98.2011.4.3
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