January 1, 2008Journal of Veterinary Medical ScienceOpen Access

The Effect of 7.2% Hypertonic Saline Solution with 6% Dextran 70 on Cardiac Contractility as Observed by an Echocardiography in Normovolemic and Anesthetized Dogs

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Why the study?

Does 7.2% hypertonic saline solution with or without 6% dextran 70 improve cardiac contractility in normovolemic and anesthetized dogs?

Population

Normovolemic and anesthetized dogs

Comparison

7.2% hypertonic saline solution or HSS with 6%… vs Isotonic saline solution (ISS)

Design

Preclinical

Authors

KSKazuyuki SuzukiRakuno Gakuen University MOMasato Otake YSYuuto SAIDA

Discussion

Member takes

Implication

Hypertonic saline augments EF via preload and afterload without direct inotropy in dogs; hypothesis-generating, leaves open clinical relevance.

Structured PICO

Does 7.2% hypertonic saline solution with or without 6% dextran 70 improve cardiac contractility in normovolemic and anesthetized dogs?

Population

Normovolemic and anesthetized dogs

Intervention

7.2% hypertonic saline solution (HSS) or HSS with 6% dextran 70 (HSD)

Comparator

Isotonic saline solution (ISS)

Outcome

Hemodynamic status and cardiac contractility (measured by left ventricular end-systolic volume index [ESVI] and ejection fraction [EF] via echocardiography)surrogate

The positive inotropic effects of hypertonic saline solutions in dogs appear to be driven by increased preload and decreased systemic vascular resistance rather than direct changes in myocardial contractility.

Cite This Study

Suzuki et al. (2008) studied this question.

synapsesocial.com/papers/6a83ac035dc232c69262c5c4 https://doi.org/10.1292/jvms.70.89

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January 1, 2008Journal of Veterinary Medical ScienceOpen Access

The Effect of 7.2% Hypertonic Saline Solution with 6% Dextran 70 on Cardiac Contractility as Observed by an Echocardiography in Normovolemic and Anesthetized Dogs

View Full Paper

Ask AI

Bookmark

Why the study?

Does 7.2% hypertonic saline solution with or without 6% dextran 70 improve cardiac contractility in normovolemic and anesthetized dogs?

Population

Normovolemic and anesthetized dogs

Comparison

7.2% hypertonic saline solution or HSS with 6%… vs Isotonic saline solution (ISS)

Design

Preclinical

Authors

KSKazuyuki SuzukiRakuno Gakuen University MOMasato Otake YSYuuto SAIDA

Discussion

Member takes

Implication

Hypertonic saline augments EF via preload and afterload without direct inotropy in dogs; hypothesis-generating, leaves open clinical relevance.

Structured PICO

Does 7.2% hypertonic saline solution with or without 6% dextran 70 improve cardiac contractility in normovolemic and anesthetized dogs?

Population

Normovolemic and anesthetized dogs

Intervention

7.2% hypertonic saline solution (HSS) or HSS with 6% dextran 70 (HSD)

Comparator

Isotonic saline solution (ISS)

Outcome

Hemodynamic status and cardiac contractility (measured by left ventricular end-systolic volume index [ESVI] and ejection fraction [EF] via echocardiography)surrogate

Cite This Study

Suzuki et al. (2008) studied this question.

synapsesocial.com/papers/6a83ac035dc232c69262c5c4 https://doi.org/10.1292/jvms.70.89

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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