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August 1, 1994AJP Heart and Circulatory Physiology

Hypertonic saline is a negative inotropic agent in normovolumic dogs

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Population

22 normovolumic, chloralose-anesthetized dogs (14 intact, 8 autonomically blocked)

Comparison

Hypertonic saline infused intravenously over 3 min vs Hyperosmotic dextrose infused intravenously over…

Design

Preclinical

Authors

PCPeter D. ConstableUrbana UniversityWMWilliam W. MuirLincoln Memorial UniversityPBPhilip F. BinkleyHeart Failure & Transplant

Discussion

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Implication

Indicates opposing inotropic effects of hyperosmotic agents in blocked canine hearts; leaves open translation to human physiology or practice.

Structured PICO

P
Population
22 normovolumic, chloralose-anesthetized dogs (14 intact, 8 autonomically blocked)
I
Intervention
Hypertonic saline (HS) infused intravenously over 3 min
C
Comparator
Hyperosmotic dextrose (HD; 2,400 mosmol/l, 4 ml/kg) infused intravenously over 3 min
O
Outcome
Inotropic effects assessed by end-systolic elastance (Ees), maximal rate of change of left ventricular pressure (dP/dtmax), and cardiac outputsurrogate

In a canine model, hypertonic saline acts as a negative inotropic agent, contrasting with the positive inotropic effect of the nonionic hyperosmotic agent dextrose.

Cite This Study

Constable et al. (1994) studied this question.

synapsesocial.com/papers/6a96db931f16343146bb9574https://doi.org/10.1152/ajpheart.1994.267.2.h667
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of hypertonic saline solution on left ventricular afterload in normovolumic dogs1995 · 12 citations
  2. 2The Effect of 7.2% Hypertonic Saline Solution with 6% Dextran 70 on Cardiac Contractility as Observed by an Echocardiography in Normovolemic and Anesthetized Dogs2008 · 5 citations
  3. 3The Effect of 7.2% Hypertonic Saline Solution on M-Mode Echocardiographic Indices in Normovolemic Dogs2006 · 9 citations
  4. 4Acute Hypotension Caused by Rapid Hypertonic Saline Infusion in Anesthetized Dogs1991 · 100 citations
  5. 5Hypertonic saline without or with dextran-70 in the treatment of experimental acute myocardial ischemia and reperfusion1999 · 17 citations