Key result
In conscious sheep, hypertonic saline resuscitation after hemorrhage rapidly increased mean arterial pressure, heart rate, and cardiac sympathetic nerve activity, but had no effect on renal sympathetic nerve activity.
Why the study?
Does hypertonic saline resuscitation improve hemodynamic function by stimulating cardiac sympathetic nerve activity in a sheep model of hemorrhage?
Population
Conscious sheep instrumented with cardiac and renal sympathetic nerve recording electrodes and a pulmonary…
Comparison
Intravenous hypertonic saline or intracarotid… vs Isotonic saline resuscitation or Gelofusine
Design
Preclinical
Authors
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Hypothesis-generating for differential sympathetic activation by hypertonic saline in hemorrhage; should not yet inform clinical resuscitation protocols.
Does hypertonic saline resuscitation improve hemodynamic function by stimulating cardiac sympathetic nerve activity in a sheep model of hemorrhage?
Hypertonic saline resuscitation improves hemodynamic function after hemorrhage through a novel neural mechanism involving cerebral stimulation of cardiac sympathetic nerve activity.
Frithiof et al. (2010) studied Hemorrhagic shock. Hypertonic saline resuscitation vs. Isotonic saline (12 ml/kg) or Gelofusine (6 ml/kg) was evaluated on Cardiac and renal sympathetic nerve activity, mean arterial pressure, heart rate, and cardiac output. In conscious sheep, hypertonic saline resuscitation after hemorrhage rapidly increased mean arterial pressure, heart rate, and cardiac sympathetic nerve activity, but had no effect on renal sympathetic nerve activity.
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