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June 1, 1992Acta Physiologica Scandinavica

Increased resistance to haemorrhage induced by intracerebroventricular infusion of hypertonic NaCl in conscious sheep

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Why the study?

Does intracerebroventricular infusion of hypertonic NaCl improve tolerance to haemorrhage in conscious sheep?

Population

Conscious sheep

Comparison

Intracerebroventricular infusion of 0.5 M NaCl… vs Control haemorrhages without concomitant i.c.v…

Design

Preclinical

Authors

HHHans HjelmqvistÖrebro UniversityJUJohan UllmanSwedish Armed ForcesUGUlf GunnarssonUmeå University

Discussion

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Implication

Hypothesis-generating for central sodium effects on hemorrhage tolerance in sheep; leaves open translation to human resuscitation.

Structured PICO

Does intracerebroventricular infusion of hypertonic NaCl improve tolerance to haemorrhage in conscious sheep?

P
Population
Conscious sheep
I
Intervention
Intracerebroventricular (i.c.v.) infusion (0.02 ml min-1) of 0.5 M NaCl starting 30 min before haemorrhage and continued throughout the experiment
C
Comparator
Control haemorrhages without concomitant i.c.v. infusion
O
Outcome
Tolerance to blood loss (volume of blood removed to induce hypotension, defined as mean systemic arterial pressure < 50 mmHg)surrogate

Elevated cerebrospinal fluid sodium concentration increases tolerance to haemorrhage and improves cardiovascular function after blood loss in a sheep model.

Cite This Study

Hjelmqvist et al. (1992) studied this question.

synapsesocial.com/papers/6a90e513263aa8e25c73cb37https://doi.org/10.1111/j.1748-1716.1992.tb09353.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sympathetic Hyperactivity Elevates Blood Pressure During Acute Cerebroventricular Infusions of Hypertonic Sait in Rats1984 · 66 citations
  2. 2Circulatory and Respiratory Effects Evoked by Hypertonic Ventriculo‐Cisternal Perfusion1975 · 12 citations
  3. 3Effects of hypertonic NaCl solution on microvascular haemodynamics in normo‐ and hypovolaemia1990 · 11 citations
  4. 4Water intake and changes in plasma and CSF composition in response to acute administration of hypertonic NaCI and water deprivation in sheep1990 · 12 citations