Key result
Intravenous infusion of hyperosmotic NaCl restored hemodynamics and resulted in indefinite survival in dogs with hemorrhagic shock, an effect dependent on intact vagal innervation.
Why the study?
Does intravenous hyperosmotic NaCl improve hemodynamics and survival in dogs with severe hemorrhagic shock, and is this dependent on the innervated lung?
Population
Dogs in severe hemorrhagic hypotension
Comparison
Intravenous infusion of hyperosmotic NaCl vs Intra-aortic infusion of hyperosmotic NaCl, or…
Design
Preclinical
Authors
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Supports vagal-pulmonary mechanism in canine shock models; leaves open translation to human resuscitation.
Does intravenous hyperosmotic NaCl improve hemodynamics and survival in dogs with severe hemorrhagic shock, and is this dependent on the innervated lung?
The full hemodynamic and survival benefits of hyperosmotic NaCl in hemorrhagic shock depend on its first passage through the pulmonary circulation with intact vagal innervation.
Lopes et al. (1981) studied Severe hemorrhagic hypotension (n=143). Hyperosmotic NaCl vs. Intra-aortic injection or intravenous injection with vagal blockade was evaluated on Hemodynamic recovery and long-term survival. Intravenous infusion of hyperosmotic NaCl restored hemodynamics and resulted in indefinite survival in dogs with hemorrhagic shock, an effect dependent on intact vagal innervation.
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