September 1, 1990Acta Physiologica Scandinavica

Effects of hypertonic NaCl solution on microvascular haemodynamics in normo‐ and hypovolaemia

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Why the study?

Does a 7.5% NaCl infusion improve microvascular hemodynamics compared to 0.9% NaCl in hamsters with hemorrhagic shock?

Population

Hamsters in normovolemia and hemorrhagic shock (acute bleeding to a hypotension level of about 40 mmHg)

Comparison

Single, 10-min, 350-microliters intravenous… vs Identical infusion of 0.9% NaCl

Design

Preclinical

Authors

EBEliete BouskelaUniversidade do Estado do Rio de Janeiro WGW. GramppLund University SMStefan MellanderNU Hospital Group

Discussion

Member takes

Implication

Hypertonic saline may aid hemodynamics in animal hemorrhagic shock; leaves open translation to human resuscitation pending trials.

Structured PICO

Does a 7.5% NaCl infusion improve microvascular hemodynamics compared to 0.9% NaCl in hamsters with hemorrhagic shock?

Population

Hamsters in normovolemia and hemorrhagic shock (acute bleeding to a hypotension level of about 40 mmHg)

Intervention

Single, 10-min, 350-microliters intravenous infusion of 7.5% NaCl

Comparator

Identical infusion of 0.9% NaCl

Outcome

Microvascular hemodynamics (mean arterial pressure, arteriolar blood flow, vessel diameters) in the hamster cheek pouchsurrogate

Hypertonic saline infusion improves mean arterial pressure and microvascular blood flow in a hamster model of hemorrhagic shock.

Cite This Study

Bouskela et al. (1990) studied this question.

synapsesocial.com/papers/6a96db206b29a448da8248b3 https://doi.org/10.1111/j.1748-1716.1990.tb08978.x

View Full Paper

Ask AI

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September 1, 1990Acta Physiologica Scandinavica

Effects of hypertonic NaCl solution on microvascular haemodynamics in normo‐ and hypovolaemia

View Full Paper

Ask AI

Bookmark

Why the study?

Does a 7.5% NaCl infusion improve microvascular hemodynamics compared to 0.9% NaCl in hamsters with hemorrhagic shock?

Population

Hamsters in normovolemia and hemorrhagic shock (acute bleeding to a hypotension level of about 40 mmHg)

Comparison

Single, 10-min, 350-microliters intravenous… vs Identical infusion of 0.9% NaCl

Design

Preclinical

Authors

EBEliete BouskelaUniversidade do Estado do Rio de Janeiro WGW. GramppLund University SMStefan MellanderNU Hospital Group

Discussion

Member takes

Implication

Hypertonic saline may aid hemodynamics in animal hemorrhagic shock; leaves open translation to human resuscitation pending trials.

Structured PICO

Does a 7.5% NaCl infusion improve microvascular hemodynamics compared to 0.9% NaCl in hamsters with hemorrhagic shock?

Population

Hamsters in normovolemia and hemorrhagic shock (acute bleeding to a hypotension level of about 40 mmHg)

Intervention

Single, 10-min, 350-microliters intravenous infusion of 7.5% NaCl

Comparator

Identical infusion of 0.9% NaCl

Outcome

Microvascular hemodynamics (mean arterial pressure, arteriolar blood flow, vessel diameters) in the hamster cheek pouchsurrogate

Hypertonic saline infusion improves mean arterial pressure and microvascular blood flow in a hamster model of hemorrhagic shock.

Cite This Study

Bouskela et al. (1990) studied this question.

synapsesocial.com/papers/6a96db206b29a448da8248b3 https://doi.org/10.1111/j.1748-1716.1990.tb08978.x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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