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April 3, 2015Circulation Heart FailureOpen Access

Short-Term Intravenous Sodium Nitrite Infusion Improves Cardiac and Pulmonary Hemodynamics in Heart Failure Patients

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Key result

Short-term intravenous sodium nitrite infusion at 50 μg/kg/min increased left ventricular stroke volume from 43.22 to 51.84 mL (P=0.003) in patients with severe chronic heart failure.

Why the study?

Does short-term intravenous sodium nitrite infusion improve cardiac and pulmonary hemodynamics in patients with severe chronic heart failure?

Population

25 patients with severe chronic heart failure

Design

Cohort

Follow-up

5 minutes

Authors

JOJulian O.M. OrmerodSASayqa ArifMMMajid Mukadam

Discussion

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Member takes

Overview

Sodium nitrite shows hemodynamic promise in stable HF; leaves open its utility and safety in acute decompensated HF pending larger trials.

Structured PICO

Does short-term intravenous sodium nitrite infusion improve cardiac and pulmonary hemodynamics in patients with severe chronic heart failure?

P
Population
25 patients with severe chronic heart failure evaluated for hemodynamic effects of short-term sodium nitrite infusion.
I
Intervention
Short-term (5 minutes) intravenous sodium nitrite (NaNO2) at 10 μg/kg/min (n=8) or 50 μg/kg/min (n=17)
O
Outcome
Cardiac hemodynamics including left ventricular stroke volume, pulmonary vascular resistance, right atrial pressure, and mean arterial blood pressuresurrogate

Main Result

Absolute Event Rate: 51.84% vs 43.22%

p-value: p=0.003

Short-term intravenous sodium nitrite infusion improves cardiac output and reduces right-sided filling pressures in severe chronic heart failure, suggesting potential utility in decompensated HF.

Cite This Study

Ormerod et al. (2015) studied Severe chronic heart failure (n=25). Intravenous sodium nitrite (NaNO2) vs. Baseline was evaluated on Left ventricular stroke volume (p=0.003). Short-term intravenous sodium nitrite infusion at 50 μg/kg/min increased left ventricular stroke volume from 43.22 to 51.84 mL (P=0.003) in patients with severe chronic heart failure.

synapsesocial.com/papers/6a9fddb93a35f4a2c890e228https://doi.org/10.1161/circheartfailure.114.001716
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nitrite Therapy Improves Left Ventricular Function During Heart Failure via Restoration of Nitric Oxide–Mediated Cytoprotective Signaling2014 · 68 citations
  2. 2Reflected pressure waves in the ascending aorta: effect of glyceryl trinitrate1988 · 83 citations
  3. 3Oxidative stress and heart failure2011 · 1,241 citations