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March 6, 2014Circulation ResearchOpen Access

Nitrite Therapy Improves Left Ventricular Function During Heart Failure via Restoration of Nitric Oxide–Mediated Cytoprotective Signaling

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Why the study?

Does sodium nitrite therapy improve left ventricular function in mice with pressure-overload-induced heart failure?

Population

Mice at 10 to 12 weeks undergoing transverse aortic constriction to induce hypertrophy and heart failure.

Comparison

Sodium nitrite administered daily in drinking… vs Saline vehicle.

Design

Preclinical

Follow-up

9 weeks

Authors

SBShashi BhushanIntegral UniversityKKKazuhisa KondoDaido UniversityDPDavid J. PolhemusJohns Hopkins University

Discussion

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Member takes

Overview

Does not support clinical use of sodium nitrite in HF; leaves open translation from mouse pressure-overload models to humans.

Structured PICO

Does sodium nitrite therapy improve left ventricular function in mice with pressure-overload-induced heart failure?

P
Population
Mice at 10 to 12 weeks undergoing transverse aortic constriction (TAC) to induce hypertrophy and heart failure.
I
Intervention
Sodium nitrite (50 mg/L) administered daily in drinking water postoperative from day 1 for 9 weeks.
C
Comparator
Saline vehicle.
O
Outcome
Left ventricular dimensions and ejection fraction assessed by echocardiography at 9 weeks.surrogate

In a mouse model of pressure-overload-induced heart failure, sodium nitrite therapy preserved left ventricular function and reduced brain natriuretic peptide levels.

Cite This Study

Bhushan et al. (2014) studied this question.

synapsesocial.com/papers/6a22433353130ceb007fc151https://doi.org/10.1161/circresaha.114.301475
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Improvement in Left Ventricular Remodeling by the Endothelial Nitric Oxide Synthase Enhancer AVE9488 After Experimental Myocardial Infarction2008 · 119 citations
  2. 2Endothelial Nitric Oxide Synthase Limits Left Ventricular Remodeling After Myocardial Infarction in Mice2001 · 311 citations
  3. 3Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency2004 · 115 citations
  4. 4Nitric Oxide Protects Against Pathological Ventricular Remodeling2004 · 62 citations
  5. 5Almanac 2011: heart failure. The national society journals present selected research that has driven recent advances in clinical cardiology2011 · 2 citations