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April 21, 2009CirculationOpen Access

Unprotected Left Main Stenting in the Real World

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Key result

Elective percutaneous coronary intervention for unprotected left main disease with paclitaxel-eluting stents resulted in a 15.8% rate of major adverse cardiac events at 2-year follow-up.

Why the study?

Does percutaneous coronary intervention with paclitaxel-eluting stents improve clinical outcomes in patients with unprotected left main disease?

Population

291 patients with unprotected left main disease undergoing elective percutaneous coronary intervention. Mean…

Design

Cohort

Follow-up

2 years

Authors

BVBeatriz VaquerizoUniversitat Autònoma de BarcelonaTLThierry LefèvreInstitut Cardiovasculaire Paris SudODOlivier DarremontUniversity Health Network

Discussion

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Implication

Offers real-world benchmarks for PCI in unprotected left main; leaves open randomized comparison with bypass surgery.

Study Design

Type

Cohort (n=291)

Multicenter

Yes

Structured PICO

Does percutaneous coronary intervention with paclitaxel-eluting stents improve clinical outcomes in patients with unprotected left main disease?

P
Population
291 patients (mean age 69) undergoing elective percutaneous coronary intervention for unprotected left main disease, excluding acute MI and cardiogenic shock, followed for 2 years.
E
Exposure
Percutaneous coronary intervention with paclitaxel-eluting stents (provisional side-branch T-stenting approach used in 92% of distal LM lesions, final kissing balloon inflation in 97%).
O
Outcome
Combined end point (major adverse cardiac events) at 2-year follow-upcomposite

Elective percutaneous coronary intervention with paclitaxel-eluting stents for unprotected left main disease provides excellent acute angiographic results and favorable mid-term clinical outcomes, though side-branch stenting in bifurcation lesions increases the risk of stent thrombosis.

Cite This Study

Vaquerizo et al. (2009) conducted a cohort in Unprotected left main disease (n=291). Percutaneous coronary intervention with paclitaxel-eluting stents was evaluated on Major adverse cardiac events (combined end point). Elective percutaneous coronary intervention for unprotected left main disease with paclitaxel-eluting stents resulted in a 15.8% rate of major adverse cardiac events at 2-year follow-up.

synapsesocial.com/papers/6a9e71e6e2d0fc9581be6a9ahttps://doi.org/10.1161/circulationaha.108.804930

Topics

Women and heart disease
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Late and very late stent thrombosis following drug-eluting stent implantation in unprotected left main coronary artery: a multicentre registry2008 · 108 citations
  2. 2Clinical, Angiographic, and Procedural Predictors of Angiographic Restenosis After Sirolimus-Eluting Stent Implantation in Complex Patients2004 · 334 citations
  3. 3Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease2009 · 4,383 citations