Late and very late stent thrombosis following drug-eluting stent implantation in unprotected left main coronary artery: a multicentre registry
Key result
Elective DES for unprotected LMCA links to a ~1% stent thrombosis rate at 30 months.
- n=731
Population
731 consecutive patients with de novo lesions on unprotected left main coronary artery (LMCA) stenosis
Design
Cohort
Follow-up
29.5 ± 13.7 months
Authors
Discussion
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Implication
Low thrombosis rate with DES in unprotected LMCA supports further study; does not yet change practice.
Study Design
Type
Cohort (n=731)
Multicenter
Yes
Structured PICO
P
Population
731 consecutive patients who had sirolimus- or paclitaxel-eluting stents electively implanted in de novo lesions on unprotected LMCA, followed for a mean of 29.5 months.
E
Exposure
Elective implantation of sirolimus- or paclitaxel-eluting stent
O
Outcome
Occurrence of late and very late stent thrombosis (ST) according to Academic Research Consortium definitionssafety
Elective treatment of unprotected left main coronary artery stenosis with drug-eluting stents is associated with a low incidence (0.95%) of definite and probable stent thrombosis at approximately 2.5 years.
Cite This Study
Chieffo et al. (2008) conducted a cohort in unprotected left main coronary artery (LMCA) stenosis (n=731). Drug-eluting stent (sirolimus- or paclitaxel-eluting) implantation was evaluated on definite and probable stent thrombosis (ST). Elective treatment of unprotected left main coronary artery stenosis with drug-eluting stents was associated with a 0.95% incidence of definite or probable stent thrombosis at 29.5 months.