Why the study?
Does an index derived from a radionuclide bolus (99Tcm-labelled human serum albumin) accurately assess the severity of mitral and aortic regurgitation compared to contrast angiography?
Does an index derived from a radionuclide bolus (99Tcm-labelled human serum albumin) accurately assess the severity of mitral and aortic regurgitation compared to contrast angiography?
A radionuclide bolus-derived index of regurgitation correlates well with the severity of mitral and aortic regurgitation as assessed by contrast angiography.
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Radionuclide index may enable noninvasive regurgitation grading; leaves open prospective validation versus angiography before clinical adoption.
Mitral and aortic regurgitation was assessed from analysis of activity-time curves from right and left ventricles following the intravenous bolus injection of 99Tcm-labelled human serum albumin. The differences in the initial arrival times and the mean transit times for the ventricles were combined to provide an index of regurgitation. The mean index for 18 patients with good ventricular function and no regurgitation was -0.07 +/- 0.55 (SD) seconds. This was not significantly different from the mean value of 0.39 +/- 1.22 s obtained for 9 patients with left ventricular failure but no regurgitation. The indices for 16 patients with mitral or aortic regurgitation agreed well with the severity as assessed by contrast angiography. The mean indices for the mild, moderate and severe regurgitation groups were 2.62 +/- 1.13 s, 5.30 +/- 3.05 s and 10.15 +/- 3.62 s respectively.
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Hannan et al. (1981) studied this question.
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