Key result
Fifty-two of 61 newly emerged classical swine fever virus isolates in China from 2014-2015 belonged to subgenotype 2.1d, exhibiting unique molecular characteristics and diverging from 2.1b isolates.
Observational (n=61)
Yes
New CSFV subgenotype warrants targeted swine surveillance; leaves open vaccine efficacy questions for 2.1d strains.
INTRODUCTION: In 2014-2015, the epidemic of classical swine fever (CSF) occurred in many large-scale pig farms in different provinces of China, and a subgenotype 2.1d of CSF virus (CSFV) was newly identified. MATERIAL AND METHODS: The phylogenetic relationship, genetic diversity, and epidemic status of the 2014-2015 CSFV isolates, 18 new CSFV isolates collected in 2015, and 43 other strains isolated in 2014-2015 were fully analysed, together with 163 CSFV reference isolates. RESULTS: Fifty-two 2014-2015 isolates belonged to subgenotype 2.1d and nine other isolates belonged to subgenotype 2.1b. The two subgenotype isolates showed unique molecular characteristics. Furthermore, the 2.1d isolates were found to possibly diverge from 2.1b isolates. CONCLUSION: This study suggests that the Chinese CSFVs will remain pandemic.
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Leng et al. (2017) conducted an observational in Classical swine fever (n=61). Classical swine fever virus (CSFV) isolates vs. Reference CSFV isolates was evaluated on Phylogenetic relationship and genetic diversity. Fifty-two of 61 newly emerged classical swine fever virus isolates in China from 2014-2015 belonged to subgenotype 2.1d, exhibiting unique molecular characteristics and diverging from 2.1b isolates.
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