Key result
Fuxin decoction alleviated cardiac involvement, systemic congestion, and growth retardation while regulating immune responses and suppressing oxidation in rats with doxorubicin-induced heart failure.
Why the study?
Does Fuxin decoction improve doxorubicin-induced heart failure in rats?
Does Fuxin decoction improve doxorubicin-induced heart failure in rats?
Fuxin decoction attenuates doxorubicin-induced heart failure in rats by suppressing oxidative stress and regulating immune responses.
Hypothesis-generating in doxorubicin rat models; prospective human trials needed before any clinical consideration.
OBJECTIVE: To observe the effects of Fuxin decoction in rats with heart failure induced by doxorubicin injections. METHODS: We employed a doxorubicin-induced heart failure model to investigate the effect of Fuxin decoction. Rats were orally administered with Fuxin decoction from 10 to 40 mg/kg. Organization structure changes were assessed by histology, circulating levels of oxidative stress-related biomarkers and inflammatory cytokines were detected via enzyme-linked immunosorbent assay. RESULTS: Administration of Fuxin decoction improved the growth retardation in doxorubicin hydrochloride injection rats. Cardiac involvement was alleviated by Fuxin decoction, as well as changes of congestion systemic circulation in this rat models. Furthermore, Fuxin decoction regulates immune responses and suppresses oxidation reaction in doxorubicin hydrochloride-induced rats. CONCLUSION: Fuxin decoction might be an interesting candidate for congestive heart failure.
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Di et al. (2018) studied Doxorubicin-induced heart failure. Fuxin decoction was evaluated on Growth retardation, cardiac involvement, systemic congestion, immune responses, and oxidation reaction. Fuxin decoction alleviated cardiac involvement, systemic congestion, and growth retardation while regulating immune responses and suppressing oxidation in rats with doxorubicin-induced heart failure.
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