Key result
Belief that drug therapy causes side effects was significantly associated with reduced moderate-high medication adherence among diabetic patients (AOR 0.349).
Why the study?
Non-adherence to diabetes medication leads to therapeutic failure, and uncontrolled diabetes causes complications including hypertension, prompting evaluation of factors associated with adherence and hypertension in diabetic patients.
Cross-Sectional (n=299)
Yes
Odds Ratio: 0.349 (95% CI 0.192–0.635)
Absolute Event Rate: 31.1% vs 58.2%
p-value: p=0.001
Medication adherence is low among diabetic patients in Pakistan, and hypertension is highly prevalent, strongly associated with family history and abnormal cholesterol levels.
Low adherence linked to family dependence and side-effect beliefs may warrant counseling; leaves open causality and applicability beyond this Punjab cohort.
Introduction: Non-adherence to a drug regimen is an important issue for the management of diabetes, and it leads to therapeutic failure.Uncontrolled diabetes is a prime reason for other complications, specifically hypertension (HTN).Thus, we evaluated the factors associated with therapeutic adherence to diabetes medication and factors associated with HTN among a population with diabetes in Punjab, Pakistan.Materials and methods: A descriptive cross-sectional study was conducted from December 2015 to March 2016.Systemic sampling technique was adopted to recruit patients.The eight-item Morisky Medication Adherence Scale-8 was used to evaluate adherence.Descriptive statistics were used to elaborate on the variables, bivariate, and multivariable analyses.These were conducted to classify factors independently associated with moderate-high adherence to medication therapy and factors associated with HTN.Results: A total of 299 people completed the study, with a mean age ± standard deviation, 48.8 ± 14.6 years.One hundred and sixty-nine (56.5%) participants were men, 270 (90.3%) were married.High adherence was found in 85 (28.4%), moderate in 69 (23.1%), and low in 145 (48.5%) patients.Patients who were taking help from the family members in taking medicine correctly and patients who believe that drug therapy caused side effects were showing reduced moderate-high adherence (adjusted odds ratio [AOR] = 0.562; 95% confidence interval [CI] = 0.328, 0.961) and (AOR = 0.349; 95% CI = 0.192, 0.635), respectively.A total of 44.4% of patients had HTN as a comorbidity.Family history of HTN (AOR = 23.42;95% CI = 9.655, 56.853; p < 0.001), and abnormal cholesterol levels (AOR = 23.401;95% CI = 10.195,53.765; p = 0.01) were significantly associated with a hypertensive status of diabetic patients in our population.Conclusions: Patients who were depending on family members to take medication correctly at a proper time, and the patients who believed that drugs caused side effects were showing a reduced level of adherence to our study group.The risk factors of HTN (i.e., abnormal cholesterol levels) were prevalent among the patients of diabetes; these must be monitored and controlled.
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Hassan-Gillani et al. (2020) conducted a cross-sectional in Diabetes mellitus (n=299). Belief that drug therapy causes side effects vs. No belief that drug therapy causes side effects was evaluated on Moderate-high medication adherence (AOR 0.349, 95% CI 0.192-0.635, p=0.001). Belief that drug therapy causes side effects was significantly associated with reduced moderate-high medication adherence among diabetic patients (AOR 0.349).
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