Medication nonadherence was independently associated with a nearly four-fold increased odds of uncontrolled hypertension (adjusted OR 3.82) compared to adherent patients.
Cross-Sectional (n=436)
Yes
Does antihypertensive medication adherence improve blood pressure control in hypertensive patients?
Medication nonadherence is a major independent determinant of poor blood pressure control among hypertensive patients, highlighting the urgent need for adherence-enhancing interventions.
Odds Ratio: 3.82 (95% CI 2.45–5.97)
Absolute Event Rate: 80.83% vs 32.65%
p-value: p=<0.001
Background: Hypertension is a major noncommunicable disease in Pakistan, and suboptimal blood pressure (BP) control remains a significant public health challenge, largely influenced by poor adherence to antihypertensive medications. Objective: This study aimed to assess the prevalence of antihypertensive medication adherence and its association with BP control among hypertensive patients attending outpatient clinics in Khyber Pakhtunkhwa, Pakistan. Methodology: This analytical cross-sectional study included 436 hypertensive patients selected through consecutive sampling from tertiary care hospitals. Data were collected using a structured questionnaire and the validated Brief Medication Questionnaire. BP was measured using standardized procedures with a Medico Aneroid Sphygmomanometer AND-85 and the Omron M3 Comfort device (Omron Healthcare, Kyoto, Japan). BP control was defined as <140/90 mmHg. Data were analyzed using Statistical Package for the Social Sciences version 25 (IBM Corp., Armonk, NY). The chi-square test and multivariable binary logistic regression were used to assess associations and adjust for confounders. Results: Of 436 participants, 196 (44.95%) were adherent and 240 (55.05%) were nonadherent. BP was controlled in 178 (40.83%) patients and uncontrolled in 258 (59.17%). Controlled BP was significantly higher among adherent patients (67.35%) compared with nonadherent patients (19.17%) (P < 0.001). Nonadherence was independently associated with uncontrolled hypertension (adjusted odds ratio = 3.82; 95% confidence interval: 2.45-5.97; P < 0.001). Other significant predictors included age ≥60 years, diabetes mellitus, and longer duration of hypertension. Conclusion: Medication nonadherence is a major independent and modifiable determinant of poor BP control among hypertensive patients in Khyber Pakhtunkhwa. Targeted adherence-enhancing interventions are urgently needed in outpatient clinical settings.
Zafar et al. (Fri,) conducted a cross-sectional in Hypertension (n=436). Medication nonadherence vs. Medication adherence was evaluated on Uncontrolled hypertension (adjusted OR 3.82, 95% CI 2.45-5.97, p=<0.001). Medication nonadherence was independently associated with a nearly four-fold increased odds of uncontrolled hypertension (adjusted OR 3.82) compared to adherent patients.