Key result
Digitalis administration increased the excursion of the left ventricular margin, providing direct evidence that the drug increases the contraction of the human heart muscle.
Why the study?
Does digitalis increase left ventricular excursion in patients with normal rhythm or auricular fibrillation?
Population
5 patients. The 4 treated patients included 2 with normal rhythm and 2 with auricular fibrillation.
Comparison
Digitalis administered until a therapeutic… vs One patient served as a control; treated…
Design
Case_series
Follow-up
Days to weeks
Authors
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Early radiographic support for digitalis inotropy in humans; leaves open its net benefit in contemporary HF management.
Does digitalis increase left ventricular excursion in patients with normal rhythm or auricular fibrillation?
This early study provided objective radiographic evidence that digitalis increases the amplitude of left ventricular contraction in humans.
Cohn et al. (1924) studied Heart disease (n=5). Digitalis vs. Baseline (pre-treatment) was evaluated on Excursion of the left ventricular margin (mm). Digitalis administration increased the excursion of the left ventricular margin, providing direct evidence that the drug increases the contraction of the human heart muscle.
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