October 15, 2010Psychosomatic Medicine
Depression Predicts Elevated Endothelin-1 in Patients With Coronary Artery Disease
Key result
Higher depression symptom severity was associated with elevated endothelin-1 levels in patients with coronary artery disease, with a 14% increased likelihood per point increase in BDI score.
Why the study?
Does depression severity predict elevated circulating endothelin-1 levels in patients with coronary artery disease?
Population
101 patients with a documented history of coronary artery disease
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports hypothesis of depression-related vascular dysfunction in CAD; leaves open causality and therapeutic implications.
Study Design
Type
Observational (n=101)
Structured PICO
Does depression severity predict elevated circulating endothelin-1 levels in patients with coronary artery disease?
P
Population
101 patients with a documented history of coronary artery disease assessed for depression severity and endothelin-1 levels.
E
Exposure
Depression severity (assessed via the Beck Depression Inventory [BDI])
O
Outcome
Circulating endothelin-1 (ET-1) levels, analyzed as a log-transformed continuous variable and a dichotomous variable (≥1.16 fmol/mL)surrogate
Main Result
Odds Ratio: 1.14
Greater depression symptom severity is significantly associated with elevated endothelin-1 levels in CAD patients, identifying a potential mechanistic vulnerability for triggered ACS and poorer survival.
Cite This Study
Burg et al. (2010) conducted an observational in Coronary Artery Disease (n=101). Depression severity (Beck Depression Inventory score) vs. Lower depression severity was evaluated on Elevated endothelin-1 (≥1.16 fmol/mL) (14% increased likelihood per point increase in BDI). Higher depression symptom severity was associated with elevated endothelin-1 levels in patients with coronary artery disease, with a 14% increased likelihood per point increase in BDI score.