Key result
Strongly positive hemagglutination-inhibition titers against Col-MM virus were found in 12.5% of sera from patients with central nervous system involvement compared to 0.7% in healthy controls.
Population
Sheep red blood cells, Col-MM strain of EMC virus, and 569 human sera
Comparison
Polyvalent anions and specific antibodies vs Healthy controls and patients with other ailments
Design
Preclinical
Authors
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No clinical implications yet; hypothesis-generating for Col-MM virus in CNS disease pending neutralization data.
Cross-Sectional (n=569)
Absolute Event Rate: 12.5% vs 0.7%
A standard serological HI-test for Col-MM virus hemagglutination showed higher incidence of positive titers in patients with CNS involvement compared to controls, though these sera failed to neutralize the virus in animal experiments.
Gard et al. (1951) conducted a cross-sectional in Central nervous system involvement (n=569). Central nervous system involvement vs. Healthy humans and patients with other ailments was evaluated on Strongly positive hemagglutination-inhibition titers. Strongly positive hemagglutination-inhibition titers against Col-MM virus were found in 12.5% of sera from patients with central nervous system involvement compared to 0.7% in healthy controls.
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