Key result
Cardiac magnetic resonance imaging combining edema ratio and global relative enhancement demonstrated 84% sensitivity and 96% negative predictive value for detecting acute cellular rejection.
Why the study?
Does multi-sequential cardiac magnetic resonance imaging accurately detect sub-clinical acute cellular rejection compared to endomyocardial biopsy in heart transplant patients?
Population
73 patients after heart transplantation undergoing 146 examinations for sub-clinical cardiac allograft…
Comparison
Multi-sequential cardiac magnetic resonance… vs Endomyocardial biopsy as the standard of…
Design
Cross-sectional
Authors
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May support noninvasive rule-out of rejection; leaves open prospective validation versus biopsy before practice change.
Observational (n=73)
No
Does multi-sequential cardiac magnetic resonance imaging accurately detect sub-clinical acute cellular rejection compared to endomyocardial biopsy in heart transplant patients?
Effect estimate: AUC 0.724 for edema ratio
CMR parameters typically used for myocarditis, particularly the combination of edema ratio and global relative enhancement, demonstrate a high negative predictive value (96%) for ruling out relevant sub-clinical acute cellular rejection after heart transplantation.
Gutberlet et al. (2014) conducted an observational in Sub-clinical acute cellular rejection after heart transplantation (n=73). Cardiac magnetic resonance imaging (CMR) vs. Endomyocardial biopsy (EMB) was evaluated on Detection of relevant rejection (histological grade ≥1B) (AUC 0.724 for edema ratio). Cardiac magnetic resonance imaging combining edema ratio and global relative enhancement demonstrated 84% sensitivity and 96% negative predictive value for detecting acute cellular rejection.
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