Unveiling the Invisible: Is there a Role of CMR in Biopsy-Negative Graft Dysfunction Post-Heart Transplantation?
Key result
The presence of late gadolinium enhancement on CMR in patients with biopsy-negative graft dysfunction had no significant impact on the primary composite outcome compared to those without LGE.
Why the study?
Does the presence of LGE on CMR predict outcomes in heart transplant recipients with biopsy-negative graft dysfunction?
Population
34 heart transplant recipients with biopsy-negative graft dysfunction who underwent CMR between 2007 and 2020.
Comparison
Cardiac magnetic resonance imaging to assess the… vs Absence of late gadolinium enhancement on CMR.
Design
Editorial
Follow-up
median 3.8 years
Authors
Discussion
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Member takes
Implication
In heart transplant recipients with biopsy-negative graft dysfunction, the presence of LGE on CMR correlates with worse symptoms and hemodynamics but does not significantly impact long-term clinical outcomes.
Structured PICO
Does the presence of LGE on CMR predict outcomes in heart transplant recipients with biopsy-negative graft dysfunction?
P
Population
34 heart transplant recipients with biopsy-negative graft dysfunction who underwent CMR between 2007 and 2020, followed for a median of 3.8 years.
E
Exposure
Cardiac magnetic resonance (CMR) imaging to assess the presence of late gadolinium enhancement (LGE).
C
Comparator
Absence of late gadolinium enhancement (LGE) on CMR.
O
Outcome
Composite of all-cause mortality, re-transplantation, or persistent LVEF <50%.composite
In heart transplant recipients with biopsy-negative graft dysfunction, the presence of LGE on CMR correlates with worse symptoms and hemodynamics but does not significantly impact long-term clinical outcomes.
Limitations
- No parametric mapping techniques were tested.
- Retrospective nature and small sample size.
- Definition of biopsy-negative GD based on a 5% decrease in LVEF may be unreliable due to inter- and intraobserver variability.
- No parametric mapping techniques were tested
- Retrospective nature
- Small sample size
- Definition of biopsy-negative graft dysfunction based on a 5% decrease in LVEF may be unreliable due to inter- and intraobserver variability
Cite This Study
Sokolska et al. (2024) conducted an editorial in Biopsy-negative graft dysfunction post-heart transplantation (n=34). Presence of late gadolinium enhancement (LGE) on CMR vs. Absence of LGE on CMR was evaluated on Composite of all-cause mortality, re-transplantation, or persistent LVEF <50%. The presence of late gadolinium enhancement on CMR in patients with biopsy-negative graft dysfunction had no significant impact on the primary composite outcome compared to those without LGE.