Key result
A combined resistance and aerobic training program performed four versus two times per week will be evaluated for its effects on 24-h ambulatory blood pressure and glycosylated hemoglobin in 98 aging individuals with hypertension.
Why the study?
Acute blood pressure lowering after exercise predicts reductions after chronic exercise training, suggesting the same weekly amount of exercise performed more frequently might better control blood pressure.
Does a combined training program performed four times per week improve 24-h ambulatory blood pressure and glycosylated hemoglobin compared to two times per week in aging individuals with hypertension?
RCT (n=98)
Single-blind
Stratified randomization
No
Does a combined training program performed four times per week improve 24-h ambulatory blood pressure and glycosylated hemoglobin compared to two times per week in aging individuals with hypertension?
This study protocol outlines a randomized trial to determine if a higher weekly frequency of combined exercise training (four vs. two times per week) with equalized volume provides greater reductions in 24-h blood pressure and HbA1c in older adults with hypertension.
This RCT will test optimal frequency of combined training for BP and glycemic control in older hypertensives; extends limited dosing evidence from prior trials.
BACKGROUND: Acute blood pressure lowering after exercise seems to predict the extent of blood pressure reduction after chronic exercise training interventions. Based on that, the same weekly amount of exercise performed more frequently could be more beneficial for controlling blood pressure. PURPOSE: To compare the effects of a combined training program (resistance plus aerobic exercise) performed four or two times per week on 24-h ambulatory blood pressure and other health-related outcomes in middle-aged and older individuals with hypertension. METHODS: This study will be a randomized, parallel group, two-arm, superiority trial. Ninety-eight participants aged 50-80 years with a previous physician diagnosis of hypertension will be randomized to perform two or four sessions per week of combined training using the same total weekly overload. Primary outcomes will be 24-h ambulatory blood pressure and glycosylated hemoglobin; secondary outcomes will be endothelial function, physical fitness and quality of life. The outcomes will be assessed at baseline and at the end of 12 weeks period. RESULTS: Our conceptual hypothesis is that a combined exercise program performed four or two times per week with equalized weekly volume/overload will improve all outcomes in comparison to the baseline values, and that reductions in 24-h blood pressure and glycosylated hemoglobin will be more pronounced in the group that trained four times a week than twice. The results of this trial are expected to provide evidences to support that higher weekly frequency of combined training should be emphasized in aging adults with hypertension.
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Ferrari et al. (2021) conducted an RCT in Hypertension (n=98). Combined resistance and aerobic training program vs. Two times per week was evaluated on Change from baseline to 12 weeks in 24-h, daytime, nighttime systolic and diastolic ambulatory blood pressure, and glycosylated hemoglobin. A combined resistance and aerobic training program performed four versus two times per week will be evaluated for its effects on 24-h ambulatory blood pressure and glycosylated hemoglobin in 98 aging individuals with hypertension.
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